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172060

Sigma-Aldrich

Andrographolide

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties.

Synonym(s):

Andrographolide, Andro

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0.44 MG
270,00 $

270,00 $


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0.44 MG
270,00 $

About This Item

Empirical Formula (Hill Notation):
C20H30O5
CAS Number:
Molecular Weight:
350.45
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

270,00 $


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Quality Level

description

Merck USA index - 14, 633

Assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

chloroform: methanol (1:1): 10 mg/mL
DMSO: 15 mg/mL (Use only fresh DMSO.)

shipped in

ambient

storage temp.

2-8°C

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pharmaceutical
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format

neat

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storage temp.

2-8°C

storage temp.

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storage temp.

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storage temp.

2-8°C

General description

A bicyclic diterpenoid lactone that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Acts as an irreversible antagonist of NF-κB and AP-1 (IC50 ≤ 15 µM) activation, and prevents in vitro and in vivo T cell activation. Exerts no effect on IκBα degradation, p50 and p65 nuclear translocation. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in mouse model. Further, reported to activate PI 3K/Akt pathway.
An irreversible blocker of NF-κB and AP-1 (IC50 ≤ 15 µM) activation that displays anti-viral, anti-inflammatory, anti-apoptotic, and anti-hyperglycemic properties. Exerts no effect on IκBα degradation of nuclear translocation p50 and p65. Inhibits iNOS and Mac-1 expressions and ROS production, and prevents endotoxin shock in a mouse model. Reported to supress Cytochrome C release and apoptosis by activating the PI 3-K/Akt pathway.

Biochem/physiol Actions

Cell permeable: no
Primary Target
NF-κB and AP-1 activation
Product does not compete with ATP.
Reversible: no
Target IC50: ≤ 15 µM against NF-κB and AP-1 activation

Packaging

Packaged under inert gas

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Xia, Y.F., et al. 2004. J. Immunol.173, 4207.
Chen, J.H., et al. 2004. Biochem. Pharmacol.67, 1337.
Yu, B.C., et al. 2003. Planta Med.69, 1075.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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