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342500

Sigma-Aldrich

FK-506, Streptomyces sp.

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

Synonym(s):

FK-506, Streptomyces sp., Tacrolimus

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About This Item

Empirical Formula (Hill Notation):
C44H69NO12
CAS Number:
104987-11-3
Molecular Weight:
804.02
MDL number:
MFCD00869853
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

description

RTECS - KD4200000

Assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

off-white

solubility

DMSO: 10 mg/mL
methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

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Show Differences

1 of 4

This Item
Y0000274Y0000272Y0000271
vibrant-m

Y0000273

Oxaliplatin impurity C

vibrant-m

Y0000274

Oxaliplatin impurity D

vibrant-m

Y0000272

Oxaliplatin impurity B

Oxaliplatin European Pharmacopoeia (EP) Reference Standard

Y0000271

Oxaliplatin

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

oxaliplatin

API family

oxaliplatin

API family

oxaliplatin

API family

oxaliplatin

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
Immunosuppressant that blocks T-cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 Binding Protein, thereby reversing its effects on sarcoplamic reticulum Ca2+ release. Shown to inhibit the Ca2+-dependent phosphatase, Calcineurin (Cat. No. 539565), as well as Na+-K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Immunosuppressant that blocks T cell proliferation
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Toxic (F)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Asano, K., et al. 1996. In Vivo 10, 537.
McCall, E., et al. 1996. Circ. Res. 79, 1110.
Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877.
Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H319,H361f,H373

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Repr. 2 - STOT RE 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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