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567732

Sigma-Aldrich

Sphingosine Kinase 1 Inhibitor, SKI-178

Synonym(s):

Sphingosine Kinase 1 Inhibitor, SKI-178, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, Nʹ-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

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₹31,526.00

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1 MG
₹31,526.00

About This Item

Empirical Formula (Hill Notation):
C21H22N4O4
Molecular Weight:
394.42
UNSPSC Code:
12352200
NACRES:
NA.28

₹31,526.00

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Assay

≥92% (HPLC)

Quality Level

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

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This Item
158178T21407319856
1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrasodium salt ≥95% (HPLC)

14513

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrasodium salt

1,3-Diamino-2-hydroxypropane-N,N,N′,N′-tetraacetic acid 99%

158178

1,3-Diamino-2-hydroxypropane-N,N,N′,N′-tetraacetic acid

N,N,N′,N′-Tetramethyldiaminomethane 99%

T21407

N,N,N′,N′-Tetramethyldiaminomethane

Acetophenone-(phenyl-d5) 99 atom % D

319856

Acetophenone-(phenyl-d5)

assay

≥95% (HPLC)

assay

99%

assay

99%

assay

99% (CP)

solubility

H2O: 10 mg/mL, clear, faintly yellow

solubility

-

solubility

-

solubility

-

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

form

powder

form

-

form

-

form

-

impurities

≤12.5% water

impurities

-

impurities

-

impurities

-

General description

A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM).

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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