567737

S1P4 Receptor Antagonist, CYM50358

The S1P4 Receptor Antagonist, CYM50358 controls the biological activity of S1P4 Receptor. This small molecule/inhibitor is primarily used for Biochemicals applications.

• Synonym(s): S1P4 Receptor Antagonist, CYM50358, CYM50358
• Empirical Formula (Hill Notation): C₂₀H₁₈Cl₂N₂O₂
• CAS Number: 1314212-39-9
• Molecular Weight: 389.28
• MDL number: MFCD28386025
• UNSPSC Code: 12352200
• PubChem Substance ID: 53358422
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: CC1=CC(=CC(=C1NC(=O)C2=CC=C(O2)C3=C(C=CC(=C3)Cl)Cl)C)CN
• InChI: 1S/C20H18Cl2N2O2/c1-11-7-13(10-23)8-12(2)19(11)24-20(25)18-6-5-17(26-18)15-9-14(21)3-4-16(15)22/h3-9H,10,23H2,1-2H3,(H,24,25)
• InChI key: QWJOPXDAQCDRRM-UHFFFAOYSA-N

Description

General description

An arylcarboxamide that acts as a potent and selective sphingosine-1-phosphate receptor 4 (S1P₄) antagonist (IC₅₀ = 25 nM), among a panel of five S1P receptors. It is shown to inhibit other S1P isoforms only at much higher concentrations (IC₅₀ = 6.4 µM, 3.9 µM, 5.5 µM, and 25 µM for S1P₁, S1P₂, S1P₅, and S1P₃ (95% inhibition), respectively).

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Guerrero, M., et al. 2011. Bioorg. Med. Chem. Lett.21, 3632.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3