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568500

Sigma-Aldrich

SQ 22536

Cell-permeable adenylate cyclase inhibitor.

Synonym(s):

SQ 22536, 9-(Tetrahydro-2ʹ-furyl)adenine

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10 G
₹11,154.00

About This Item

Empirical Formula (Hill Notation):
C9H11N5O
CAS Number:
17318-31-9
Molecular Weight:
205.22
MDL number:
MFCD00210216
UNSPSC Code:
12352200
NACRES:
NA.77

₹11,154.00

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Quality Level

100

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 25 mg/mL
water: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]2(c3ncnc(c3nc2)N)C1OCCC1

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Sodium hydrogen sulfate monohydrate for analysis EMSURE®

1.06352

Sodium hydrogen sulfate monohydrate

form

solid

form

solid

form

solid

form

solid

solubility

340 g/L

solubility

340 g/L

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

1080 g/L

assay

99.99%

assay

≥99.0% dry basis (alkalimetric)

assay

≥99.0% (T)

assay

≥99.0% (alkalimetric)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

300

grade

for inorganic trace analysis

grade

ACS reagent

grade

-

grade

-

pH

4.5-6.0 (20 °C, 50 g/L in H2O)

pH

4.5-6.0 (20 °C, 50 g/L in H2O)

pH

4-7 (25 °C, 1 M in H2O)

pH

1 (20 °C, 50 g/L in H2O)

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 µM). Reduces PGE2-induced inhibition of O2·– production.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
adenylate cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 200 µM against adenylate cyclase

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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