568500

SQ 22536

Cell-permeable adenylate cyclase inhibitor.

• Synonym(s): SQ 22536, 9-(Tetrahydro-2ʹ-furyl)adenine
• Empirical Formula (Hill Notation): C₉H₁₁N₅O
• CAS Number: 17318-31-9
• Molecular Weight: 205.22
• MDL number: MFCD00210216
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white
• solubility: DMSO: 25 mg/mL; water: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [n]2(c3ncnc(c3nc2)N)C1OCCC1
• InChI: 1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
• InChI key: UKHMZCMKHPHFOT-UHFFFAOYSA-N

Description

General description

Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC₅₀ = 200 µM). Reduces PGE₂-induced inhibition of O₂^·– production.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
adenylate cyclase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 200 µM against adenylate cyclase

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.

Other Notes

Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable