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573096

Sigma-Aldrich

STAT3 Inhibitor Peptide, Cell-Permeable

≥95% (HPLC), lyophilized solid, STAT3 inhibitor, Calbiochem®

Synonym(s):

STAT3 Inhibitor Peptide, Cell-Permeable, PpYLKTK-mts, STAT3 Inhibitor IV

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About This Item

Empirical Formula (Hill Notation):
C92H157N20O24P
Molecular Weight:
1958.32
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name

STAT3 Inhibitor Peptide, Cell-Permeable, The STAT3 Inhibitor Peptide, Cell-Permeable controls the biological activity of STAT3.

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

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suitability

Salmonella spp.

suitability

Bacillus cereus (NHE), Salmonella spp.

suitability

Escherichia coli (O157:H7)

manufacturer/tradename

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manufacturer/tradename

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manufacturer/tradename

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compatibility

for use with GDS Rotor-Gene

compatibility

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compatibility

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compatibility

BioControl GDS, for use with GDS Rotor-Gene

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

application(s)

food and beverages
pathogen testing

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

technique(s)

PCR: suitable

General description

Supplied as a trifluoroacetate salt.
A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Blocker of Stat3 activation
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

H-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH

Other Notes

Turkson, J., et al. 2001. J. Biol. Chem.276, 45443.
Rojas, M., et al. 1998. Nat. Biotechnol.16, 370.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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