8.14727
Brij® 58
for synthesis
Synonym(s):
Brij® 58, Polyoxyethylene (20) cetylether, Polyethyleneglycol (20) cetylether
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About This Item
Recommended Products
Quality Level
form
solid
potency
2500 mg/kg LD50, oral (Rat)
mp
38-42 °C
transition temp
flash point >149 °C
storage temp.
2-30°C
SMILES string
O(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCCCCCCCCCCCCCCC)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCO
InChI
1S/C56H114O21/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-17-58-19-21-60-23-25-62-27-29-64-31-33-66-35-37-68-39-41-70-43-45-72-47-49-74-51-53-76-55-56-77-54-52-75-50-48-73-46-44-71-42-40-69-38-36-67-34-32-65-30-28-63-26-24-61-22-20-59-18-16-57/h57H,2-56H2,1H3
InChI key
NLMKTBGFQGKQEV-UHFFFAOYSA-N
1 of 4
This Item | B7782 | B7407 | B3533 |
---|---|---|---|
manufacturer/tradename Nalgene® 2002-0004 | manufacturer/tradename Nalgene® 2002-0008 | manufacturer/tradename Nalgene® 2002-0001 | manufacturer/tradename Nalgene® 2002-0016 |
feature with cap | feature with cap | feature with cap | feature with cap |
material polypropylene cap, round bottle, polypropylene screw closure, translucent high-density polyethylene | material polypropylene cap, polypropylene screw closure, round bottle, translucent high-density polyethylene | material polypropylene cap, polypropylene screw closure, round bottle, translucent high-density polyethylene | material polypropylene cap, polypropylene screw closure, round bottle, translucent high-density polyethylene |
capacity 125 mL | capacity 250 mL | capacity 30 mL | capacity 500 mL |
packaging pack of 12 ea | packaging pack of 12 ea | packaging pack of 12 ea | packaging pack of 12 ea |
joint Joints threaded neck (24) | joint Joints threaded neck (24) | joint Joints threaded neck (20) | joint Joints threaded neck (28) |
Application
- Potential Activity of Micafungin and Amphotericin B Co-Encapsulated in Nanoemulsion against Systemic Candida auris Infection in a Mice Model.: This study investigates the use of Brij® 58 in formulating a nanoemulsion to enhance the efficacy of micafungin and amphotericin B against systemic Candida auris infections in mice. The results suggest significant improvements in drug delivery and antifungal activity (Marena et al., 2024).
- Encapsulation of Pure Water-Stable Perovskite Nanocrystals (PNCs) into Biological Environment-Stable PNCs for Cell Imaging.: This research highlights the role of Brij® 58 in stabilizing perovskite nanocrystals, enhancing their stability and applicability in biological environments for cell imaging purposes (Zheng et al., 2024).
- Improving Drug Delivery on Candida Albicans Using Geraniol Nanoemulsion.: This paper discusses the use of Brij® 58 in geraniol nanoemulsions to enhance drug delivery against Candida albicans, showing improved antifungal effectiveness and stability (Silva Pontes et al., 2023).
- Combined Effect of Shaking Orbit and Vial Orientation on the Agitation-Induced Aggregation of Proteins.: Brij® 58 is utilized in this study to prevent protein aggregation in pharmaceutical formulations during agitation, highlighting its importance in maintaining protein stability (Dasnoy et al., 2024).
Analysis Note
Water (K. F.): ≤ 3.0 %
Due to its specific melting range the product may be solid, liquid, a solidified melt or a supercooled melt.
Legal Information
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
302.0 °F - closed cup
Flash Point(C)
150 °C - closed cup
Certificates of Analysis (COA)
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Articles
As new “bath salt” drugs such as methylone, ethylone, mephedrone, butylone and other methcathinone analogs increase in popularity, toxicologists require native and labeled certified reference materials to accurately identify and quantify the new compounds in patient samples.
The combination of ion-exchange SPE with the HILIC HPLC separation provides a novel approach for the testing of problematic bath salt compounds.
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LC-MS/MS is a powerful tool that brings numerous benefits to the clinical sample analysis arena. However, due to the complexity of the instrumentation there are some unique challenges that also accompany these benefits. Even following sample extraction and cleanup, matrix effects from the samples can cause interferences or impact ionization efficiency.
Protocols
Separation of 3,4-Methylenedioxypyrovalerone HCl (MDPV) solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Buphedrone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; 3-Fluoromethcathinone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Butylone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Ethylone hydrochloride, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; 4-Fluoromethcathinone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Mephedrone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Methylone hydrochloride, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material; Methedrone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
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