8.14815

Sodium chlorite

(25% solution in water) for synthesis

• Synonym(s): Chlorous acid, sodium salt
• UNSPSC Code: 12352302
• NACRES: NA.22
• Grade: for synthesis; synthesis grade
• Form: liquid

Properties

• grade: for synthesis; synthesis grade
• Quality Level: 200
• vapor pressure: 20 hPa ( 20 °C)
• form: liquid
• potency: 1136 mg/kg LD₅₀, oral (Rat)
• pH: 12-13 (20 °C in H₂O)
• bp: ≥100 °C/1013 hPa
• mp: <-3 °C
• density: 1.20-1.25 g/cm³ at 20 °C
• storage temp.: 2-30°C

Description

Application

Sodium chlorite (NaClO₂) can be used as an oxidizing agent for the conversion of:

• Aldehydes to corresponding carboxylic acids under mild reaction conditions in the presence of scavengers such as sulfamic acid or resorcinol.
• Primary alcohols to carboxylic acids in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and NaOCl.
• Aliphatic and aromatic thiols to the corresponding disulfides.
• Aryl boronic acids to phenols via ipso-hydroxylation.
• Cyclic benzylic ethers and N-protected cyclic benzylic amines to benzolactones and benzolactams.
• Alkenes to epoxides using aldehydes as promoters.
• Alkenes and cycloalkenes to 1, 2 diols via osmium-catalyzed Sharpless asymmetric dihydroxylation.

It can also be used in combination with Br₂ to synthesize 2-carboxyazetidin-2-ones from furanylazetidinones.

Analysis Note

Assay (iodometric): 23.0 - 26.0 %
Density (d 20 °C/ 4 °C): 1.200 - 1.220

Safety Information

• Pictograms: GHS05,GHS06,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H290 - H302 - H311 - H314 - H373 - H400
• Precautionary Statements: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P314
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1 - STOT RE 2
• Target Organs: spleen
• Supplementary Hazards: EUH032
• Storage Class Code: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable