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MABC209

Sigma-Aldrich

Anti-MUC13 Antibody, clone 2E11.1

clone 2E11.1, from mouse

Synonym(s):

Mucin-13, MUC-13, Down-regulated in colon cancer 1

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25 ML
₩6,66,145
50 ML
₩12,67,837

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

₩6,66,145

Please contact Customer Service for Availability
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biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2E11.1, monoclonal

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_149038

UniProt accession no.

Q9H3R2

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SRE0037

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β-Glucuronidase from limpets (Patella vulgata) aqueous solution

SRE0093

β-Glucuronidase from limpets (Patella vulgata)

β-Glucuronidase from Helix pomatia Type H-2, aqueous solution, ≥85,000 units/mL

G0876

β-Glucuronidase from Helix pomatia

form

aqueous solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300

β-glucuronidase activity

≥100,000 units/mL

β-glucuronidase activity

≥20,000,000 units/g protein, 150,000-250,000 units/mL

β-glucuronidase activity

-

β-glucuronidase activity

-

secondary activity

≤8,000 units/mL sulfatase

secondary activity

≤7,500 units/mL sulfatase

secondary activity

-

secondary activity

≤7,500 units/mL sulfatase

General description

Mucin-13 (MUC-13) is also called Down-regulated in colon cancer 1 (DRCC1). MUC-13 is an epithelial and hemopoietic transmembrane mucin that is likely involved in cell signaling. MUC-13 is highly expressed in epithelial tissues (especially in gastrointestinal and respiratory tracts) as well as kidney, small intestine, appendix and stomach.

Immunogen

Epitope: This antibody recognizes the cytoplasmic domain within the Beta subunit of MUC-13.
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human MUC-13.

Application

Detect Mucin using this mouse monoclonal antibody, Anti-MUC13 Antibody, clone 2E11.1 validated for use in western blotting & IHC (Paraffin).
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Western Blotting Analysis: 0.5 µg/mL from a representative lot detected MUC-13 in 10 µg of human kidney tissue lysate.

Immunohistochemistry Analysis: a 1:500 dilution from a representative lot detected MUC-13 in human ilium tissues.

Quality

Evaluated by Western Blotting in human small intestine tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MUC-13 in 10 µg of human small intestine tissue lysate.

Target description

~33 and ~60 kDa observed. Swiss-Prot describes a molecular weight of ~55 kDa Due post-translational modification, this protein is cleaved resulting in beta subunit (~33 kDa) and an alpha subunit (Williams, S. J., et al. (2001). J Biol Chem. 276(21):18327-18336. Maher, D. M., et al. (2011). Mol Cancer Res. 9(5):531-537.). Uncharacterized band(s) may be observed in some cell lysates.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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