D6003

Digoxin

analytical standard

• Synonym(s): 12β-Hydroxydigitoxin
• Empirical Formula (Hill Notation): C₄₁H₆₄O₁₄
• CAS Number: 20830-75-5
• Molecular Weight: 780.94
• Beilstein: 77011
• EC Number: 244-068-1
• MDL number: MFCD00003674
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798818
• NACRES: NA.24

Properties

• biological source: plant (Digitalis lanata)
• Quality Level: 100
• grade: analytical standard
• Assay: ≥95.0% (HPLC)
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• solubility: methanol: methylene chloride (1:1): 0.5%, clear, colorless
• application(s): food and beverages; forensics and toxicology; veterinary
• format: neat
• functional group: ketone
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4
• InChI: 1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
• InChI key: LTMHDMANZUZIPE-PUGKRICDSA-N
• Gene Information: human ... ATP1A1(476), ATP1A2(477), ATP1A3(478), ATP1A4(480), ATP1B1(481), ATP1B2(482), ATP1B3(483), FXYD2(486)

Description

Application

Digoxin may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography techniques.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).

A cardiac glycoside, substrate for Pgp.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H300,H331,H373
• Precautionary Statements: P260 - P264 - P271 - P301 + P310 - P304 + P340 + P311 - P314
• Hazard Classifications: Acute Tox. 2 Oral - Acute Tox. 3 Inhalation - STOT RE 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves