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PHR1253

Supelco

Acarbose

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Acarbose, 4",6"-Dideoxy-4"-([1S]-[1,4,6/5]-4,5,6-trihydroxy-3-hydroxymethyl-2-yclohexenylamino)-maltotriose

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About This Item

Empirical Formula (Hill Notation):
C25H43NO18
CAS Number:
56180-94-0
Molecular Weight:
645.60
EC Number:
260-030-7
MDL number:
MFCD00869592
UNSPSC Code:
41116107
PubChem Substance ID:
329823256
NACRES:
NA.24
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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. Y0000500
traceable to USP 1000521

API family

acarbose

CofA

current certificate can be downloaded

analyte chemical class(es)

oligosaccharides

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages
pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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1 of 4

This Item
G1544N6537SAB1410600
Anti-β-Glucuronidase (N-Terminal) antibody produced in rabbit ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

G5420

Anti-β-Glucuronidase (N-Terminal) antibody produced in rabbit

Anti-GFP, N-terminal antibody produced in rabbit ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

G1544

Anti-GFP, N-terminal antibody produced in rabbit

Anti-NPTII antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

N6537

Anti-NPTII antibody produced in rabbit

Anti-GUSB antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

SAB1410600

Anti-GUSB antibody produced in rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

mol wt

antigen 60 kDa

mol wt

-

mol wt

antigen 30 kDa

mol wt

antigen 74.7 kDa

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acarbose is an oral antidiabetic drug, a glucosidase inhibitor used in the management of non-insulin-dependent diabetes mellitus (NIDDM).[1]

Application

Acarbose may be used as a pharmaceutical reference standard in determining the concentration of the analyte in pharmaceutical formulations by chromatography techniques.[1][2][3]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Modified tetrasaccharide that acts as a reversible α -glucosidase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9057 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

  • Specification Sheet

    • Certificates of Analysis (COA)

    Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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    Bacterial glucuronidase as general marker for oncolytic virotherapy or other biological therapies
    Hess M, et al.
    Journal of Translational Medicine, 9(1), 172-172 (2011)
    Michael Hess et al.
    Journal of translational medicine, 9, 172-172 (2011-10-13)
    Oncolytic viral tumor therapy is an emerging field in the fight against cancer with rising numbers of clinical trials and the first clinically approved product (Adenovirus for the treatment of Head and Neck Cancer in China) in this field. Yet
    Release of the recombinant proteins, human serum albumin, ?-glucuronidase, glycoprotein B from human cytomegalovirus, and green fluorescent protein, in root exudates from transgenic tobacco and their effects on microbes and enzymatic activities in soil
    Sabharwal N, et al.
    Plant Physiology and Biochemistry, 45(6-7), 464-469 (2007)
    Vascular-specific expression of GUS and GFP reporter genes in transgenic grapevine (Vitis vinifera L. cv. Albarin
    Gago J, et al.
    Plant Physiology and Biochemistry, 49(4), 413-419 (2011)
    Impact of ubiquitous inhibitors on the GUS gene reporter system: evidence from the model plants Arabidopsis, tobacco and rice and correction methods for quantitative assays of transgenic and endogenous GUS
    Fior S, et al.
    Plant methods, 5(1), 19-19 (2009)
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