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PHR1506

Supelco

Metformin Related Compound C

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

N,N-Dimethyl-1,3,5-triazine-2,4,6-triamine, N,N-Dimethyl-[1,3,5]-triazine-2,4,6-triamine

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About This Item

Empirical Formula (Hill Notation):
C5H10N6
CAS Number:
Molecular Weight:
154.17
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1396342

API family

metformin

CofA

current certificate can be downloaded

packaging

pkg of 50 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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1 of 4

This Item
WHA10370111WHA10370105WHA10370172
manufacturer/tradename

Whatman 10370119, Whatman Article No. 28414768 (US reference)

manufacturer/tradename

Whatman 10370111, Whatman Article No. 28414767 (US reference)

manufacturer/tradename

Whatman 10370105, Whatman Article No. 28414766 (US reference)

manufacturer/tradename

Whatman 10370172, Whatman Article No. 28414772 (US reference)

pore size

~3.0 μm (Grade GF 8)

pore size

~3.0 μm (Grade GF 8)

pore size

~3.0 μm (Grade GF 8)

pore size

~3.0 μm (Grade GF 8)

diam.

47 mm

diam.

200 mm

diam.

90 mm

diam.

-

material

circles white glass membrane (with inorganic binder)

material

circles white glass membrane (with inorganic binder)

material

circles white glass membrane (with inorganic binder)

material

sheets white glass microfiber filter (with inorganic binder)

parameter

Fast flow rate

parameter

Fast flow rate

parameter

Fast flow rate

parameter

Fast flow rate

sterility

non-sterile

sterility

-

sterility

-

sterility

non-sterile

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the widely used anti-diabetic drug, metformin, that belongs to the biguanide class of compounds.[1]

Application

This pharmaceutical secondary standard can also be used as follows:

  • Simultaneous determination of vildagliptin, metformin, and metformin-related compounds (A, B, and C) in tablets using a high-performance liquid chromatography-tandem mass spectrometry method (HPLC-MS/MS)[2]
  • Development of a hydrophilic interaction liquid chromatography method combined with diode array detection (HILIC-DAD) for the simultaneous quantification of impurities in the combined dosage tablet of rosuvastatin and metformin
  • Analysis of metformin and its related impurities in bulk samples by normal phase high-performance liquid chromatographic (HPLC) method[3]

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2896 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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