T9159

Trichloroacetic acid

BioXtra, ≥99.0%

• Synonym(s): TCA
• Linear Formula: Cl₃CCOOH
• CAS Number: 76-03-9
• Molecular Weight: 163.39
• Beilstein: 970119
• EC Number: 200-927-2
• MDL number: MFCD00004177
• UNSPSC Code: 12352106
• PubChem Substance ID: 24900586
• NACRES: NB.22

Properties

• grade: BioPerformance Certified
• Quality Level: 200
• vapor density: <1 (vs air)
• vapor pressure: 1 mmHg ( 51 °C)
• product line: BioXtra
• Assay: ≥99.0%
• impurities: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• ign. residue: ≤0.03%
• refractive index: n20/D 1.62 (lit.)
• bp: 196 °C (lit.)

Description

General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

Application

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Trichloroacetic acid has been used:

• for protein precipitation
• as a component in the extract solution used for the measurement of malondialdehyde and glutathione
• to precipitate the transfected and treated cells in [³H]-thymidine incorporation assay

Biochem/physiol Actions

TCA might act as a carcinogen, targeting liver. It might be used as an acid decalcifying agent. TCA helps in nuclear staining.

Safety Information

• Pictograms: GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H314,H410
• Precautionary Statements: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class Code: 8B - Non-combustible corrosive hazardous materials
• WGK: WGK 2
• Flash Point(F): >235.4 °F - closed cup
• Flash Point(C): > 113 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves