571261

Piperidine

biotech. grade, ≥99.5%

• Synonym(s): Hexahydropyridine
• Empirical Formula (Hill Notation): C₅H₁₁N
• CAS Number: 110-89-4
• Molecular Weight: 85.15
• Beilstein: 102438
• EC Number: 203-813-0
• MDL number: MFCD00005979
• UNSPSC Code: 12352005
• PubChem Substance ID: 329758271
• NACRES: NA.21
• Grade: biotech. grade
• Assay: ≥99.5%
• Technique(s): DNA sequencing: suitable
• Bp: 106 °C (lit.); 106 °C
• Vapor pressure: 23 mmHg ( 20 °C)

Properties

• grade: biotech. grade
• Quality Level: 100
• vapor density: 3 (vs air)
• vapor pressure: 23 mmHg ( 20 °C)
• Assay: ≥99.5%
• form: liquid
• technique(s): DNA sequencing: suitable
• impurities: <0.3% water
• refractive index: n20/D 1.452 (lit.)
• bp: 106 °C (lit.); 106 °C
• mp: −13 °C (lit.)
• solubility: organic solvents: soluble(lit.); water: miscible(lit.)
• density: 0.862 g/mL at 20 °C (lit.)
• λ: 1 cm path, H₂O reference
• UV absorption: λ: 290 A_max: <1.000; λ: 370 A_max: <0.050
• SMILES string: C1CCNCC1
• InChI: 1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2
• InChI key: NQRYJNQNLNOLGT-UHFFFAOYSA-N

Description

General description

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The ¹H NMR spectrum of piperidine has been recorded.

Application

Fits Applied Biosystems 431 and 433A peptide synthesizers.

Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

Safety Information

• Pictograms: GHS02,GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H225,H302,H311 + H331,H314
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 60.8 °F - closed cup
• Flash Point(C): 16 °C - closed cup