07039

(R)-(+)-α-Lipoic acid

≥98.0% (HPLC)

• Synonym(s): (R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
• Empirical Formula (Hill Notation): C₈H₁₄O₂S₂
• CAS Number: 1200-22-2
• Molecular Weight: 206.33
• MDL number: MFCD01631142
• UNSPSC Code: 12352202
• PubChem Substance ID: 329748332
• NACRES: NA.32

Properties

• Quality Level: 100; 200
• Assay: ≥98.0% (HPLC)
• optical purity: enantiomeric excess: ≥98.0% (HPLC)
• mp: 48-52 °C (lit.)
• storage temp.: −20°C
• SMILES string: OC(=O)CCCC[C@@H]1CCSS1; OC(=O)CCCC[C@@H]1CCSS1
• InChI: 1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
• InChI key: AGBQKNBQESQNJD-SSDOTTSWSA-N

Description

Biochem/physiol Actions

(R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

identity confirmed by LC-MS

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable