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Key Documents

07841

Sigma-Aldrich

(R)-Mevalonic acid 5-phosphate lithium salt

95% (TLC)

Synonym(s):

(R)-3-Hydroxy-3-methyl-5-phosphonooxy-pentanoic acid lithium salt, (R)-5-Phosphomevalonate lithium salt, R-MVAP-Li

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About This Item

Empirical Formula (Hill Notation):
C6H13O7P · xLi+
CAS Number:
Molecular Weight:
228.14 (free acid basis)
UNSPSC Code:
12352106
NACRES:
NA.25

Quality Level

Assay

95% (TLC)

optical activity

[α]/D -3.2±0.5°, c = 0.1 in 0.2 M HCl

storage temp.

−20°C

SMILES string

[P](=O)([O-])([O-])OCC[C@@](O)(CC(=O)[O-])C

InChI

1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1

InChI key

OKZYCXHTTZZYSK-ZCFIWIBFSA-K

Related Categories

Application

Mevalonic acid 5-phosphate (M5P) may be used as a reference material in assays for the separation or detection of mevalonic acid 5-phosphate. Mevalonic acid 5-phosphate is the immediate precursor of isopentenyl pyrophosphate (IPP) and the mevalonate pathway which leads to isoprenoid biosynthesis. Mevalonic acid 5-phosphate may be used as a substrate to identify and characterize phosphomevalonate kinase(s).

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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