07841

(R)-Mevalonic acid 5-phosphate lithium salt

95% (TLC)

• Synonym(s): (R)-3-Hydroxy-3-methyl-5-phosphonooxy-pentanoic acid lithium salt, (R)-5-Phosphomevalonate lithium salt, R-MVAP-Li
• Empirical Formula (Hill Notation): C₆H₁₃O₇P · xLi⁺
• CAS Number: 73566-35-5
• Molecular Weight: 228.14 (free acid basis)
• UNSPSC Code: 12352106
• NACRES: NA.25

Properties

• Quality Level: 100
• Assay: 95% (TLC)
• optical activity: [α]/D -3.2±0.5°, c = 0.1 in 0.2 M HCl
• storage temp.: −20°C
• SMILES string: [P](=O)([O-])([O-])OCC[C@@](O)(CC(=O)[O-])C
• InChI: 1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
• InChI key: OKZYCXHTTZZYSK-ZCFIWIBFSA-K

Description

Application

Mevalonic acid 5-phosphate (M5P) may be used as a reference material in assays for the separation or detection of mevalonic acid 5-phosphate. Mevalonic acid 5-phosphate is the immediate precursor of isopentenyl pyrophosphate (IPP) and the mevalonate pathway which leads to isoprenoid biosynthesis. Mevalonic acid 5-phosphate may be used as a substrate to identify and characterize phosphomevalonate kinase(s).

Biochem/physiol Actions

Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable