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317861

Sigma-Aldrich

Phenyl isothiocyanate

99%, for protein sequencing

Synonym(s):

PITC

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100 μL
₩8,19,613

₩8,19,613


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100 μL
₩8,19,613

About This Item

Linear Formula:
C6H5NCS
CAS Number:
Molecular Weight:
135.19
Beilstein:
471392
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21

₩8,19,613


Please contact Customer Service for Availability
A recombinant, preservative-free antibody is available for your target. Try ZRB1532

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type

for protein sequencing

Quality Level

Assay

99%

form

liquid

refractive index

n20/D 1.6515 (lit.)

bp

218 °C (lit.)
221 °C

mp

−21 °C (lit.)

solubility

water: insoluble

density

1.132 g/mL at 20 °C (lit.)

functional group

isothiocyanate

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1 of 4

This Item
78780139742P1034
assay

99%

assay

≥99.0%

assay

98%

assay

≥99% (GC)

solubility

water: insoluble

solubility

water: insoluble

solubility

water: insoluble

solubility

-

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

bp

218 °C (lit.), 221 °C

bp

218 °C (lit.)

bp

218 °C (lit.)

bp

218 °C (lit.)

density

1.132 g/mL at 20 °C (lit.)

density

1.13 g/mL at 20 °C, 1.132 g/mL at 20 °C (lit.)

density

1.132 g/mL at 20 °C (lit.)

density

1.132 g/mL at 20 °C (lit.)

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

2-8°C

Application

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.
Used for derivatizing N-terminal amino acids of proteins for automated sequential analysis.[1] Synthon for dithiadiazafulvalenes.[2]

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

190.4 °F - closed cup

Flash Point(C)

88 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Anika Steffen et al.
The EMBO journal, 23(4), 749-759 (2004-02-07)
The Rho-GTPase Rac1 stimulates actin remodelling at the cell periphery by relaying signals to Scar/WAVE proteins leading to activation of Arp2/3-mediated actin polymerization. Scar/WAVE proteins do not interact with Rac1 directly, but instead assemble into multiprotein complexes, which was shown
Local F-actin network links synapse formation and axon branching.
Chia, PH; Chen, B; Li, P; Rosen, MK; Shen, K
Cell null
Patricia Kunda et al.
Current biology : CB, 13(21), 1867-1875 (2003-11-01)
In animal cells, GTPase signaling pathways are thought to generate cellular protrusions by modulating the activity of downstream actin-regulatory proteins. Although the molecular events linking activation of a GTPase to the formation of an actin-based process with a characteristic morphology
Marco A Salazar et al.
The Journal of biological chemistry, 278(49), 49031-49043 (2003-09-25)
Tuba is a novel scaffold protein that functions to bring together dynamin with actin regulatory proteins. It is concentrated at synapses in brain and binds dynamin selectively through four N-terminal Src homology-3 (SH3) domains. Tuba binds a variety of actin
Reply to "Reduced CYFIP2 Stability by Arg87 Variants Causing Human Neurological Disorders".
Mitsuko Nakashima et al.
Annals of neurology, 86(5), 805-806 (2019-09-12)

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