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92283

Sigma-Aldrich

Polymyxin B solution

20 mg/mL in H2O

Synonym(s):

Aerosporin, Polymyxin B, Polymyxin B Sulfate

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1 MG
₩381,500

About This Item

CAS Number:
1405-20-5
MDL number:
MFCD00131991
UNSPSC Code:
51283106
NACRES:
NA.85

₩381,500

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biological source

Bacillus polymyxa (fermentation)

Quality Level

200

form

liquid

optical activity

[α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)

concentration

20 mg/mL in H2O

color

colorless to slightly yellow

solubility

H2O: soluble 20 mg/mL

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria
fungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

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This Item
SAB4300059SAB4300609SAB4300397
Anti-LYVE1 antibody produced in rabbit affinity isolated antibody

SAB4300606

Anti-LYVE1 antibody produced in rabbit

Anti-phospho-MYOD1 (pSer200) antibody produced in rabbit affinity isolated antibody

SAB4300059

Anti-phospho-MYOD1 (pSer200) antibody produced in rabbit

Anti-FLT4 antibody produced in rabbit affinity isolated antibody

SAB4300609

Anti-FLT4 antibody produced in rabbit

Anti-MYOD1 (Ab-200) antibody produced in rabbit affinity isolated antibody

SAB4300397

Anti-MYOD1 (Ab-200) antibody produced in rabbit

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

species reactivity

mouse, human, rat

species reactivity

rat, human, mouse

species reactivity

human

species reactivity

mouse, human, rat

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.

Application

Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.[1]

Biochem/physiol Actions

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.

Packaging

10ml, 125ml

Preparation Note

This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.

Other Notes

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0001435856
BCCJ6544
BCCB9362
BCBJ8934V
BCBJ0486V

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