A2324

Amikacin sulfate salt

aminoglycoside antibiotic

• CAS Number: 149022-22-0
• MDL number: MFCD00167477
• UNSPSC Code: 41116107
• PubChem Substance ID: 24890648
• NACRES: NA.85

Properties

• biological source: synthetic
• Quality Level: 200
• form: powder
• concentration: 691-806 μg/mg (dry)
• color: white to off-white
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria; mycobacteria
• Mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: OS(O)(=O)=O.NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O
• InChI: 1S/C22H43N5O13.H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);(H2,1,2,3,4)/t6-,7+,8+,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;/m0./s1
• InChI key: HIBICIOPDUTNRR-BOEHXBESSA-N

Description

General description

Chemical structure: aminoglycoside

Application

Amikacin is an aminoglycoside antibiotic commonly used in the treatment of drug-resistant mycobacteria . It is used to study organism-directed delivery of antibiotics as well as drug resistance .

Biochem/physiol Actions

Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading.

Antibacterial spectrum: Gram-negative and gram-positive bacteria.

Other Notes

Aminoglycoside antibiotic. Derivative of kanamycin.

Keep container tightly closed in a dry and well-ventilated place.

Quality

Amikacin:Sulfate ratio 1:1.8

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves