A2327

Adrenomedullin 52 human

≥90% (HPLC), powder

• Empirical Formula (Hill Notation): C₂₆₄H₄₀₆N₈₀O₇₇S₃
• CAS Number: 148498-78-6
• Molecular Weight: 6028.73
• MDL number: MFCD00211549
• UNSPSC Code: 51111800
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥90% (HPLC)
• form: powder
• UniProt accession no.: P35318
• storage temp.: −20°C
• Gene Information: human ... ADM(133)

Description

Amino Acid Sequence

Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

General description

Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.

Application

Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis.

Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves