A2504
6-Aminocaproic acid
≥99% (titration), powder
Synonym(s):
ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
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About This Item
Linear Formula:
H2N(CH2)5CO2H
CAS Number:
Molecular Weight:
131.17
Beilstein:
906872
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
biological source
synthetic
Quality Level
Assay
≥99% (titration)
form
powder
technique(s)
cell culture | mammalian: suitable
color
white
mp
207-209 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
SMILES string
NCCCCCC(O)=O
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
Gene Information
human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)
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Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
404.6 - 408.2 °F
Flash Point(C)
207 - 209 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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