A3734

1-Azakenpaullone

≥97% (HPLC)

• Synonym(s): 9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one
• Empirical Formula (Hill Notation): C₁₅H₁₀BrN₃O
• CAS Number: 676596-65-9
• Molecular Weight: 328.16
• MDL number: MFCD09037522
• UNSPSC Code: 12352200
• PubChem Substance ID: 329770845
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (HPLC)
• form: powder
• storage condition: protect from light
• color: gray-brown
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1
• InChI: 1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
• InChI key: NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

1-Azakenpaullone (AZP) can stimulate the transcription of β-catenin-related genes. This compound can induce the multiplication and replication of β cell.

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs.

1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.

Caution

air sensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable