B107

L-BMAA hydrochloride

≥97% (NMR), powder

• Synonym(s): S(+)-2-Amino-3-(methylamino)propionic acid hydrochloride
• Empirical Formula (Hill Notation): C₄H₁₀N₂O₂ · HCl
• CAS Number: 16012-55-8
• Molecular Weight: 154.60
• MDL number: MFCD00055227
• UNSPSC Code: 12352209
• PubChem Substance ID: 329773160
• NACRES: NA.32

Properties

• Quality Level: 100
• Assay: ≥97% (NMR)
• form: powder
• optical activity: [α]/D +21 to +31°, c = 0.5 M in 0.1 M HCl(lit.)
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: soluble (solutions may be stored for several days at 4 °C)
• storage temp.: −20°C
• SMILES string: Cl.CNC[C@H](N)C(O)=O
• InChI: 1S/C4H10N2O2.ClH/c1-6-2-3(5)4(7)8;/h3,6H,2,5H2,1H3,(H,7,8);1H/t3-;/m0./s1
• InChI key: VDXYGASOGLSIDM-DFWYDOINSA-N

Description

General description

L-BMAA hydrochloride/β-N-methylamino-l-alanine (BMAA) is a cyanobacterial neurotoxin.

Application

L-BMAA hydrochloride has been used as a standard to compare all the samples in the analysis of β-N-methylamino-l-alanine (BMAA) isomers in desert crust material. It has also been used as an additive with f/2+Si medium to treat the cells of Phaeodactylum tricornutum and Thalassiosira weissflogii to study its effect on them.

Biochem/physiol Actions

L-BMAA hydrochloride helps to block the addition of heparan sulfate to glypican-1. It possesses unusual glutamate receptor binding properties. It may cause amyotrophic lateral sclerosis/Lou Gehrig′s disease.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves