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Key Documents

B8271

Sigma-Aldrich

Bromoacetic acid N-hydroxysuccinimide ester

≥95%, powder

Synonym(s):

2,5-Dioxopyrrolidin-1-yl 2-bromoacetate, N-Hydroxysuccinimide bromoacetate

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About This Item

Empirical Formula (Hill Notation):
C6H6BrNO4
CAS Number:
Molecular Weight:
236.02
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NC.07

Quality Level

Assay

≥95%

form

powder

reaction suitability

reagent type: cross-linking reagent

solubility

acetone: 25 mg/mL
DMF: soluble

functional group

NHS ester

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(N1OC(CBr)=O)CCC1=O

InChI

1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2

InChI key

NKUZQMZWTZAPSN-UHFFFAOYSA-N

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Application

A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.

Caution

The bromoacetyl group is light sensitive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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