B8271
Bromoacetic acid N-hydroxysuccinimide ester
≥95%, powder
Synonym(s):
2,5-Dioxopyrrolidin-1-yl 2-bromoacetate, N-Hydroxysuccinimide bromoacetate
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About This Item
Empirical Formula (Hill Notation):
C6H6BrNO4
CAS Number:
Molecular Weight:
236.02
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NC.07
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Quality Level
Assay
≥95%
form
powder
reaction suitability
reagent type: cross-linking reagent
solubility
acetone: 25 mg/mL
DMF: soluble
functional group
NHS ester
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(N1OC(CBr)=O)CCC1=O
InChI
1S/C6H6BrNO4/c7-3-6(11)12-8-4(9)1-2-5(8)10/h1-3H2
InChI key
NKUZQMZWTZAPSN-UHFFFAOYSA-N
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Application
A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0.
Caution
The bromoacetyl group is light sensitive.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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