C1055

Cromakalim

• Synonym(s): (±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol
• Empirical Formula (Hill Notation): C₁₆H₁₈N₂O₃
• CAS Number: 94470-67-4
• Molecular Weight: 286.33
• MDL number: MFCD00133201
• UNSPSC Code: 12352200
• PubChem Substance ID: 24891962
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• storage temp.: 2-8°C
• SMILES string: CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N
• InChI: 1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
• InChI key: TVZCRIROJQEVOT-CABCVRRESA-N
• Gene Information: rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)

Description

Application

Cromakalim has been used:

• as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
• as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
• as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Biochem/physiol Actions

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves