C271

CX546

≥98% (HPLC), solid

• Synonym(s): 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
• Empirical Formula (Hill Notation): C₁₄H₁₇NO₃
• CAS Number: 215923-54-9
• Molecular Weight: 247.29
• MDL number: MFCD01860868
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277960
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: white to off-white
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(N1CCCCC1)c2ccc3OCCOc3c2
• InChI: 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
• InChI key: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

Description

General description

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

Application

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

Biochem/physiol Actions

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Positive AMPA glutamate receptor modulator.

Caution

Photosensitive

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves