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D3630

Sigma-Aldrich

Diphenhydramine hydrochloride

≥98% (HPLC)

Synonym(s):

2-Diphenylmethoxy-N,N-dimethylethylamine hydrochloride, N-(2-Diphenylmethoxyethyl)-N,N-dimethylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H21NO · HCl
CAS Number:
Molecular Weight:
291.82
EC Number:
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

originator

Johnson & Johnson

SMILES string

Cl[H].CN(C)CCOC(c1ccccc1)c2ccccc2

InChI

1S/C17H21NO.ClH/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;/h3-12,17H,13-14H2,1-2H3;1H

InChI key

PCHPORCSPXIHLZ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

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Application

Diphenhydramine hydrochloride has been used:
as a reference compound to study the long duration of action of antihistamine bilastine in vivo
to detect its embryotoxicity by embryonic stem cell test (EST) using cardiomyocyte differentiation and osteoblasts differentiation
as an antihistamine in experimental studies

Biochem/physiol Actions

H1 histamine receptor antagonist
Diphenhydramine hydrochloride (DPH) is an antihistaminic agent that relieves symptoms of hypersensitive reactions. It exhibits antimuscarinic and marked sedative effects. DPH is also used to prevent nausea, vomiting and vertigo of various causes. In addition, it acts as a potential therapeutic for insomnia.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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