D3648

Diamide

• Synonym(s): 1,1′-Azobis(N,N-dimethylformamide), N,N,N′,N′-Tetramethylazodicarboxamide, Azodicarboxylic acid bis(dimethylamide), Diazenedicarboxylic acid bis(N,N-dimethylamide), TMAD
• Linear Formula: (CH₃)₂NCON=NCON(CH₃)₂
• CAS Number: 10465-78-8
• Molecular Weight: 172.19
• Beilstein: 1910409
• EC Number: 233-951-7
• MDL number: MFCD00008318
• UNSPSC Code: 12352102
• PubChem Substance ID: 24278365
• NACRES: NA.22

Properties

• Assay: ≥98% (TLC)
• Quality Level: 200
• form: powder
• mp: 113-115 °C
• solubility: water: 19.60-21.00 mg/mL, clear to slightly hazy, orange
• storage temp.: −20°C
• SMILES string: CN(C)C(=O)\N=N\C(=O)N(C)C
• InChI: 1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
• InChI key: VLSDXINSOMDCBK-BQYQJAHWSA-N

Description

Application

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves