D3876
2′-Deoxyuridine 5′-monophosphate disodium salt
Sigma Grade
Synonym(s):
dUMP
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About This Item
Linear Formula:
C9H11N2O8PNa2
CAS Number:
Molecular Weight:
352.15
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Recommended Products
biological source
synthetic (organic)
Quality Level
grade
Sigma Grade
Assay
≥98% (HPLC)
form
powder
storage temp.
−20°C
SMILES string
[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI
1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
InChI key
WXIVKKBDJOCRNB-UHFFFAOYSA-N
Related Categories
General description
2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).
Application
2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
2′-Deoxyuridine 5′-monophosphate disodium salt has been used:
- in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
- to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
- in thymidylate synthase activity assay Helicobacter pylori
Biochem/physiol Actions
2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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