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D5891

Sigma-Aldrich

1,1-Dimethyl-4-phenylpiperazinium iodide

≥98% (TLC or titration)

Synonym(s):

DMPP

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1 EA
MYR 68.00

MYR 68.00


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1 EA
MYR 68.00

About This Item

Empirical Formula (Hill Notation):
C12H19IN2
CAS Number:
Molecular Weight:
318.20
Beilstein:
3746109
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

MYR 68.00


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Quality Level

Assay

≥98% (TLC or titration)

form

powder

mp

234-238 °C (lit.)

solubility

H2O: 21 mg/mL

storage temp.

−20°C

SMILES string

[I-].C[N+]1(C)CCN(CC1)c2ccccc2

InChI

1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1

InChI key

XFZJGFIKQCCLGK-UHFFFAOYSA-M

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This Item
CLS4854CLS4884CLS4826
feature

DNase free, barrier: no, endotoxin free, graduation: no, RNase free, filter: no, packaging: rack, disposable

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, packaging: rack

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, packaging: rack

feature

DNase free, RNase free, barrier: no, disposable, endotoxin free, filter: no, graduation

manufacturer/tradename

Corning 4815

manufacturer/tradename

Corning 4854

manufacturer/tradename

Corning 4884

manufacturer/tradename

Corning 4826

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

material

natural tip, polypropylene

packaging

rack of 200

packaging

rack of 200

packaging

rack of 200

packaging

rack of 96

L

83 mm

L

83 mm

L

83 mm

L

-

Application

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:
  • to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice[1]
  • to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP[2]
  • to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon[3]

Biochem/physiol Actions

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist.[1] It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.[4]

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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