D7128

L-Dihydroorotic acid

≥99%

• Synonym(s): 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid, L-Hydroorotic acid, Dihydro-L-orotic acid
• Empirical Formula (Hill Notation): C₅H₆N₂O₄
• CAS Number: 5988-19-2
• Molecular Weight: 158.11
• MDL number: MFCD00085339
• UNSPSC Code: 12352204
• PubChem Substance ID: 24894080
• NACRES: NA.83

Properties

• Quality Level: 200
• Assay: ≥99%
• form: powder
• mp: 254-255 °C (dec.) (lit.)
• SMILES string: OC(=O)[C@@H]1CC(=O)NC(=O)N1
• InChI: 1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
• InChI key: UFIVEPVSAGBUSI-REOHCLBHSA-N

Description

Application

L-Dihydroorotic acid has been used as a substrate in dihydroorotate dehydrogenase (DHODH) assay.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves