D7571

Dimaprit dihydrochloride

≥98% (NMR)

• Synonym(s): Carbamimidothioic acid, 3-(dimethylamino)propyl ester, hydrochloride (1:2), Dimaprit-2HCl
• Empirical Formula (Hill Notation): C₆H₁₅N₃S · 2HCl
• CAS Number: 23256-33-9
• Molecular Weight: 234.19
• MDL number: MFCD00069260
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798854
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (NMR)
• form: powder
• color: white to off-white
• solubility: H₂O: ≥50 mg/mL
• originator: Roche
• storage temp.: −20°C
• SMILES string: Cl.Cl.CN(C)CCCSC(N)=N
• InChI: 1S/C6H15N3S.2ClH/c1-9(2)4-3-5-10-6(7)8;;/h3-5H2,1-2H3,(H3,7,8);2*1H
• InChI key: DFWCPLGXFMSUCW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Selective histamine receptor H2 agonist.

The histamine H2 receptor influences various cardiovascular responses, including vasodilation and cardiac rhythm, regulates gastric acid secretion, and also plays a role in the immune system by inhibiting antibody production, T cell proliferation and cytokine production. Histamine receptors are members of the GPCR family, and H2 mediates cell signaling via internalization and interaction with the GTPase dynamin.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable