F8384

Flavin adenine dinucleotide disodium salt hydrate

suitable for cell culture, BioReagent

• Synonym(s): FAD, FAD-Na₂, Riboflavin 5′-adenosine diphosphate disodium salt
• Empirical Formula (Hill Notation): C₂₇H₃₁N₉Na₂O₁₅P₂ · xH₂O
• CAS Number: 84366-81-4
• Molecular Weight: 829.51 (anhydrous basis)
• Beilstein: 5326842
• MDL number: MFCD08277021
• UNSPSC Code: 12352207
• PubChem Substance ID: 24894962
• NACRES: NA.75

Properties

• biological source: bovine milk
• product line: BioReagent
• Assay: ≥95%
• form: powder
• technique(s): cell culture | mammalian: suitable
• solubility: water: 50 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [Na+].[Na+].[H]O[H].Cc1cc2N=C3C(=O)NC(=O)N=C3N(C[C@H](O)[C@H](O)[C@H](O)COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)n5cnc6c(N)ncnc56)c2cc1C
• InChI: 1S/C27H33N9O15P2.2Na.H2O/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;;1H2/q;2*+1;/p-2/t14-,15+,16+,19-,20+,21+,26+;;;/m0.../s1
• InChI key: GXTPHHZYFMAGLX-UJXBNFGUSA-L

Description

General description

Flavin adenine dinucleotide (FAD) is a redox cofactor of flavoproteins, such as cytochrome-b₅ reductase enzyme.[1] With the help of nicotinamide adenine dinucleotide phosphate (NADPH), FAD can be reduced to form FADH₂.[2]

Application

Flavin adenine dinucleotide (FAD) is used as a redox cofactor (electron carrier) by flavoproteins including succinate dehydrogenase (complex), α-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2, AMID), folate/FAD-dependent tRNA methyltransferases, and N-hydroxylating flavoprotein monooxygenases. FAD is a component of the pyruvate dehydrogenase complex.

Flavin adenine dinucleotide disodium salt hydrate has been used as a component in the extraction buffer for plant tissue extraction.[3] It has also been used to study its effects on infarct areas of middle cerebral artery occlusion (MCAO) induced mice.[4]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves