G9048

GANT61

≥98% (HPLC)

• Synonym(s): 2,2′-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethyl-benzenamine, NSC 136476
• Empirical Formula (Hill Notation): C₂₇H₃₅N₅
• CAS Number: 500579-04-4
• Molecular Weight: 429.60
• MDL number: MFCD14635408
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: >2 mg/mL
• storage temp.: 2-8°C
• SMILES string: N2(C(N(CCC2)Cc4c(cccc4)N(C)C)c3ccncc3)Cc1c(cccc1)N(C)C
• InChI: 1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
• InChI key: KVQOGDQTWWCZFX-UHFFFAOYSA-N

Description

Biochem/physiol Actions

GANT61 blocks hedgehog pathway signaling by inhibiting the transcripional activity of Gli1 (IC50 = 5 μM). GANT 61 led to a regression of 22Rv1 human prostate tumor cell xenografts in nude mice.

GANT61 is a Hh pathway Gli Inhibitor.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable