GS70

GST P1-1, Recombinant Human

• Synonym(s): DFN7, FAEES3, GST3, GSTP, HEL-S-22, glutathione S-transferase pi
• UNSPSC Code: 12352200
• NACRES: NA.26

Properties

• biological source: human
• Quality Level: 100
• recombinant: expressed in E. coli
• Assay: >95% (SDS-PAGE)
• form: frozen liquid
• specific activity: 60.45 units/mg protein
• mol wt: 23 kDa
• storage temp.: −70°C
• Gene Information: human ... GSTP1(2950)

Description

General description

using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1.0 mM) in 100 mM KPO4 (pH 6.5) at room temperature.

Biochem/physiol Actions

Glutathione S-transferase pi 1 (GSTP1) is an enzyme that in humans is encoded by the GSTP1 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

Storage and Stability

The enzyme should be used by the end-user customer within 1 year of receipt.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable