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Key Documents

I8907

Sigma-Aldrich

Interferon β from rat

≥95%, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture

Synonym(s):

IFN-β

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About This Item

MDL number:
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

rat

Quality Level

recombinant

expressed in CHO cells

Assay

≥95%

form

lyophilized powder

mol wt

~20 kDa

packaging

pkg of 1 vial

concentration

≥100000 units/mL

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

rat ... Ifnb1(24481)

Biochem/physiol Actions

Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
Interferon β belongs to the type 1 interferon family pf proteins. It is also needed for the inhibition of tumor cell growth via cell death, S-phase increase and mediating differentiation. It is also important for bone homeostasis.

Physical form

Lyophilized from phosphate buffered saline (PBS) containing 125 mM trehalose.

Analysis Note

The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV). The cytopathic effect of 50% is produced with approximately 1 unit/ml interferon. Since there is no international rat interferon β standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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