I9785

Imidazolo-oxindole PKR inhibitor C16

≥98% (HPLC)

• Synonym(s): 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
• Empirical Formula (Hill Notation): C₁₃H₈N₄OS
• CAS Number: 608512-97-6
• Molecular Weight: 268.29
• MDL number: MFCD06735404
• UNSPSC Code: 12352200
• PubChem Substance ID: 329815469
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• color: yellow to orange-brown
• solubility: DMSO: 12 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4
• InChI: 1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
• InChI key: VFBGXTUGODTSPK-BAQGIRSFSA-N

Description

Application

Imidazolo-oxindole PKR inhibitor C16 has been used:

• to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
• to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
• to augment eukaryotic translation initiation factor 2 (eIF2) activity

Biochem/physiol Actions

C16 exhibits a neuroprotective role in adult brain injuries.

Imidazolo-oxindole PKR inhibitor C16 is a selectiv inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2).

Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable