I9785
Imidazolo-oxindole PKR inhibitor C16
≥98% (HPLC)
Synonym(s):
6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
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About This Item
Empirical Formula (Hill Notation):
C13H8N4OS
CAS Number:
Molecular Weight:
268.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥98% (HPLC)
color
yellow to orange-brown
solubility
DMSO: 12 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
O=C1NC2=CC=C3C(SC=N3)=C2/C1=C/C4=CNC=N4
InChI
1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
InChI key
VFBGXTUGODTSPK-BAQGIRSFSA-N
Related Categories
Application
Imidazolo-oxindole PKR inhibitor C16 has been used:
- to rescue fear memory deficits and restore long-term potentiation (LTP) impairment in mice
- to inhibit the strong induction of interferon stimulated genes (ISGs) after plasmid transfection in HeLa-S3 cells
- to augment eukaryotic translation initiation factor 2 (eIF2) activity
Biochem/physiol Actions
C16 exhibits a neuroprotective role in adult brain injuries.
Imidazolo-oxindole PKR inhibitor C16 is a selectiv inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2).
Imidazolo-oxindole PKR inhibitor C16 is a selective inhibitor of RNA-dependent protein kinases (PKR, Eif2ak2). C16 is a first reported, potent and selective PKR inhibitor. Its inhibition effect on PKR is ATP-binding site directed. C16 specifically inhibits the apoptotic PKR/eIF2a signaling pathway without stimulating the proliferative mTOR/p70S6K signaling mechanism.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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