L7134

Luteinizing hormone releasing hormone human acetate salt

≥98% (HPLC), powder

• Synonym(s): Gonadoliberin, Gonadotropin releasing hormone, LH-RH
• Empirical Formula (Hill Notation): C₅₅H₇₅N₁₇O₁₃
• CAS Number: 71447-49-9
• Molecular Weight: 1182.29
• MDL number: MFCD00133489
• UNSPSC Code: 51111800
• PubChem Substance ID: 329817648
• NACRES: NA.32

Properties

• Quality Level: 200
• Assay: ≥98% (HPLC)
• form: powder
• mol wt: M_r 1182.33
• UniProt accession no.: P01148
• storage temp.: −20°C
• SMILES string: CC(O)=O.CC(O)=O.CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N6CCC[C@H]6C(=O)NCC(N)=O
• InChI: 1S/C55H75N17O13.2C2H4O2/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36;2*1-2(3)4/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60);2*1H3,(H,3,4)/t36-,37-,38-,39-,40-,41-,42-,43-;;/m0../s1
• InChI key: QOVPLTBEZAJSHY-VIRDRFNDSA-N
• Gene Information: human ... GNRH1(2796)

Description

Amino Acid Sequence

Glp-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

Application

Luteinizing hormone releasing hormone human acetate salt has been used:

• for synchronization of the ovulations[1]
• for pre-absorption of the anti-GnRH antibody in staining procedures[2][3]
• to study pituitary sensitivity to GnRH in presence of endocrine disrupting compound[4]

Biochem/physiol Actions

Hypothalamic peptide that stimulates release of gonadotrophins from anterior pituitary, thus regulating reproductive functions.

Stimulates release of gonadotrophins from anterior pituitary.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Components

pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂

Other Notes

free peptide

Lyophilized from 0.5% acetic acid

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H360
• Precautionary Statements: P201 - P308 + P313
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves