M6045

2-Methyl-4-isothiazolin-3-one hydrochloride

≥99%

• Synonym(s): MIT hydrochloride, Methylisothiazolinone hydrochloride
• Empirical Formula (Hill Notation): C₄H₅NOS · HCl
• CAS Number: 26172-54-3
• Molecular Weight: 151.61
• Beilstein: 3993054
• EC Number: 247-499-3
• MDL number: MFCD06804636
• UNSPSC Code: 51102829
• PubChem Substance ID: 24897073
• NACRES: NA.76

Properties

• Quality Level: 200
• Assay: ≥99%
• Mode of action: protein synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN1SC=CC1=O
• InChI: 1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H
• InChI key: SJXPQSRCFCPWQQ-UHFFFAOYSA-N

Description

General description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.

Application

Methylisothiazolinone (MIT HCl) has been used:

• as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
• to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.

Safety Information

• Pictograms: GHS06,GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H301,H314,H317,H410
• Precautionary Statements: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1
• Supplementary Hazards: EUH071
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves