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N6037

Sigma-Aldrich

Neridronate

≥97% (NMR), solid, bone resorption inhibitor

Synonym(s):

6-Amino-1-hydroxyhexylidene bisphosphonic acid, Neridronic acid, Nerixia

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100 μL
₩884,471

About This Item

Empirical Formula (Hill Notation):
C6H17NO7P2
CAS Number:
Molecular Weight:
277.15
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77

₩884,471


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Product Name

Neridronate, ≥97% (NMR), solid

description

may contain <1% (w/w) inorganic salts

Quality Level

Assay

≥97% (NMR)

form

solid

color

white

solubility

H2O: >5 mg/mL

storage temp.

2-8°C

SMILES string

NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O

InChI

1S/C6H17NO7P2/c7-5-3-1-2-4-6(8,15(9,10)11)16(12,13)14/h8H,1-5,7H2,(H2,9,10,11)(H2,12,13,14)

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This Item
Z740227Z740234Z740229
material

aluminum support, silica gel 60 matrix

material

aluminum support, silica gel 60 matrix

material

aluminum support, silica gel 60 matrix (C18)

material

aluminum support, silica gel 60 matrix

technique(s)

HPTLC: suitable, thin layer chromatography (TLC): suitable

technique(s)

thin layer chromatography (TLC): suitable

technique(s)

HPTLC: suitable, thin layer chromatography (TLC): suitable

technique(s)

thin layer chromatography (TLC): suitable

feature

binder Polymeric, fluorescent indicator: no

feature

binder Polymeric, fluorescent indicator: no

feature

binder Polymeric, fluorescent indicator

feature

binder Polymeric, fluorescent indicator

pore size

60 Å pore size

pore size

60 Å medium pore diameter

pore size

60 Å pore size

pore size

60 Å medium pore diameter

packaging

pkg of 25 ea

packaging

pkg of 25 ea

packaging

pkg of 20 ea

packaging

pkg of 100 ea

manufacturer/tradename

EMD Millipore® 1.05547.0001

manufacturer/tradename

EMD Millipore® 1.05553.0001

manufacturer/tradename

EMD Millipore® 1.05559.0001

manufacturer/tradename

EMD Millipore® 1.05534.0001

Biochem/physiol Actions

Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta, an "orphan disease" characterized by a fragility of the bone enough to be named the "illness of bones of crystal".
Neridronate is a bone resorption inhibitor. It is used to treat Osteogenesis Imperfecta.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Rika Aoki et al.
Cardiovascular research, 104(2), 326-336 (2014-09-06)
At birth, dynamic changes occur in serum components and haemodynamics, such as closure of the ductus arteriosus (DA). A previous study demonstrated that, in full-term human neonates, serum osmolality decreased transiently after birth, but recovered over the next few days.

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