O1141

Olanzapine

≥98% (HPLC)

• Synonym(s): LY-170053, 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine
• Empirical Formula (Hill Notation): C₁₇H₂₀N₄S
• CAS Number: 132539-06-1
• Molecular Weight: 312.43
• Beilstein: 7655141
• MDL number: MFCD00866702
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818894
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow
• solubility: DMSO: >15 mg/mL
• originator: Eli Lilly
• storage temp.: 2-8°C
• SMILES string: CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24
• InChI: 1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3
• InChI key: KVWDHTXUZHCGIO-UHFFFAOYSA-N
• Gene Information: human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356), HTR2C(3358)

Description

Biochem/physiol Actions

Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist.

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Pictograms: GHS06
• Signal Word: Danger
• Hazard Statements: H301,H315,H317,H336
• Precautionary Statements: P261 - P264 - P271 - P280 - P301 + P310 - P302 + P352
• Hazard Classifications: Acute Tox. 3 Oral - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3