O3636

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

powder

• Synonym(s): ODQ
• Empirical Formula (Hill Notation): C₉H₅N₃O₂
• CAS Number: 41443-28-1
• Molecular Weight: 187.15
• MDL number: MFCD00792620
• UNSPSC Code: 41106305
• PubChem Substance ID: 24278054
• NACRES: NA.32

Properties

• Assay: ≥98% (TLC)
• Quality Level: 200
• form: powder
• color: pale yellow
• solubility: ethanol: 1.2 mg/mL; DMSO: 5 mg/mL; H₂O: insoluble
• storage temp.: 2-8°C
• SMILES string: O=C1ON=C2C=Nc3ccccc3N12
• InChI: 1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
• InChI key: LZMHWZHOZLVYDL-UHFFFAOYSA-N
• Gene Information: human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

Application

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one has been used as a oxidising agent for  affinity selection-mass spectrometry (AS-MS) compound binding assay, as a soluble guanylate cyclase (sGC) inhibitor to inhibit S-nitroso-N-acetyl-DL-penicillamine (SNAP)-induced cGMP production.

Biochem/physiol Actions

H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) non competitively inhibits the action of nitric oxide-sensitive guanylyl cyclase and results in a supposedly irreversible oxidation of the prosthetic heme group. ODQ has been used to study the role of cyclic guanosine monophosphate (cGMP) pathway in nitric oxide (NO) signal transduction.

Selective inhibitor of nitric oxide-sensitive guanylyl cyclase.

Caution

Hygroscopic

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves