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P0036

Sigma-Aldrich

PP121

≥98% (HPLC)

Synonym(s):

1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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10 μG
₹56,298.20

About This Item

Empirical Formula (Hill Notation):
C17H17N7
CAS Number:
1092788-83-4
Molecular Weight:
319.36
MDL number:
MFCD12912434
UNSPSC Code:
12352200
PubChem Substance ID:
329819987
NACRES:
NA.77

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Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ncnc2n(nc(-c3cnc4[nH]ccc4c3)c12)C5CCCC5

InChI

1S/C17H17N7/c18-15-13-14(11-7-10-5-6-19-16(10)20-8-11)23-24(12-3-1-2-4-12)17(13)22-9-21-15/h5-9,12H,1-4H2,(H,19,20)(H2,18,21,22)

InChI key

NVRXTLZYXZNATH-UHFFFAOYSA-N

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PP121 ≥98% (HPLC)

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AZ12601011 ≥98% (HPLC)

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PP242 hydrate ≥98% (HPLC), powder

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PP242 hydrate

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: >10 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: >10 mg/mL

color

off-white

color

white to off-white

color

white to light brown

color

off-white

Biochem/physiol Actions

PP121 blocks the vascular endothelial growth factor (VEGF) receptor and its related signaling events.[1] It also inhibits tumor cell proliferation by targeting oncogenic tyrosine kinase and phosphoinositide 3-kinases (PI3Ks).[1]
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases.
PP121 is a dual inhibitor of tyrosine and phosphoinositide kinases. PP121 is the first inhibitor active on both Tyrosine kinases and the phosphatidylinositol-3-OH kinase (PI(3)K) family. The inhibitor is not effecting other serine-threonine protein kinases.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    069K4600V
    069K4600

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