P1584

Peptidyl Arginine Deiminase from rabbit skeletal muscle

buffered aqueous glycerol solution, ≥200 units/mg protein (Bradford)

• Synonym(s): Protein arginine iminohydrolase
• CAS Number: 75536-80-0
• EC Number: 3.5.3.15 (BRENDA, IUBMB)
• MDL number: MFCD00165226
• UNSPSC Code: 12352204
• NACRES: NA.54

Properties

• form: buffered aqueous glycerol solution
• Quality Level: 300
• specific activity: ≥200 units/mg protein (Bradford)
• relevant disease(s): arthritis (rheumatoid )
• shipped in: dry ice
• storage temp.: −70°C

Description

General description

Peptidyl arginine deiminase is the enzyme that converts arginine into citrulline.

Application

Peptidyl arginine deiminase has been used in a study that assessed promising novel biomarkers for the early diagnosis of rheumatoid arthritis. It has also been used in a study to investigate the autopathogenic correlation of periodontitis and rheumatoid arthritis.

Biochem/physiol Actions

Calcium is required for peptidylarginine deiminase activity in vitro.

Unit Definition

One unit will produce 1 μmole of N-α-benzoylcitrulline ethyl ester from BAEE per hr at 55 °C at pH 7.2.

Physical form

Solution in 20 mM Tris-HCl, pH 7.4, containing 10 mM 2-mercaptoethanol, 1 mM EDTA and 10% glycerol

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H334
• Precautionary Statements: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable