P1742

Prealbumin from human plasma

lyophilized powder

• Synonym(s): Thyroxine binding prealbumin, Transthyretin
• CAS Number: 87090-18-4
• MDL number: MFCD00132069
• UNSPSC Code: 12352202
• NACRES: NA.25

Properties

• biological source: human plasma
• Quality Level: 200
• Assay: ≥95% (SDS-PAGE)
• form: lyophilized powder
• technique(s): immunoelectrophoresis: suitable; immunoprecipitation (IP): suitable
• impurities: Infectious agents, tested
• solubility: H₂O: soluble 1 mg/mL
• ε (extinction coefficient): 13.5 at 280 nm at 1%
• UniProt accession no.: P02766
• storage temp.: −20°C
• Gene Information: human ... TTR(7276)

Description

General description

Human prealbumin is a product of chromosome 18. It is a serum protein, synthesized primarily in the liver. It is a tetrameric protein with a molecular weight of 55 kDa. Human prealbumin is composed of four identical non-covalently bound monomers of 127 amino acid residues arranged with tetrahedral symmetry.

Application

Human prealbumin was used to study reduced transthyretin expression in sera of lung cancer.

Prealbumin from human plasma has been used as a positive control in immunoprecipitation as a reference standard in quantitative rocket immunoelectrophoresis for quantification of cerebrospinal fluid.

Biochem/physiol Actions

Human prealbumin has been observed in carcinoid tumors.

Prealbumin levels are indictors of malnutrition and may be modulated during inflammation. It is regarded as potential marker of protein energy malnutrition (PEM) during chronic kidney failure supported dialysis. Low levels of prealbumin poses high risk to heart failure (HF).

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing sodium phosphate and NaCl

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves