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Key Documents

P4154

Sigma-Aldrich

Polyinosinic acid potassium salt

Homopolymer

Synonym(s):

Poly(I) potassium salt

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About This Item

CAS Number:
26936-41-4
MDL number:
MFCD00131982
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

Assay

≥98% (TLC)

form

lyophilized powder

solubility

water: 4.80-5.20 mg/mL, clear to hazy, colorless to faintly yellow

storage temp.

−20°C

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Application

Polyinosinic acid (Poly(I)) is a homopolymer of inosine that may be used with polycytidylic acid (poly(C)) to form the double-stranded homopolymer (Poly(I) • Poly(C)). TLR3 recognizes double-stranded RNA and is a major effector of the immune response against viral pathogens. (Poly(I) • Poly(C)) is a used as a model RNA to study cell signaling at the level of TLR3. Poly(IC) is a TRIF-dependent toll-like receptor-3 (TLR3) ligand.

Preparation Note

Prepared from IDP using polynucleotide phosphorylase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
14160909
089M4006V
059M4045V
12181121
078M4037V

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