P4498

Pravastatin sodium salt hydrate

≥98% (HPLC), powder

• Synonym(s): (βR, δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β, δ,6-trihydroxy-2-methyl-8[(2S)-2-methyl-1-oxobutoxyl]-1-naphthaleneheptanoic acid sodium hydrate, Eptastatin sodium salt hydrate
• Empirical Formula (Hill Notation): C₂₃H₃₅O₇Na · xH₂O
• CAS Number: 81131-70-6
• Molecular Weight: 446.51 (anhydrous basis)
• MDL number: MFCD00887601
• UNSPSC Code: 12352200
• PubChem Substance ID: 329820206
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white
• mp: 171.2-173 °C
• solubility: H₂O: >10 mg/mL
• originator: Bristol-Myers Squibb
• storage temp.: 2-8°C
• SMILES string: [Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O
• InChI: 1S/C23H36O7.Na/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28;/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28);/q;+1/p-1/t13-,14-,16+,17+,18+,19-,20-,22-;/m0./s1
• InChI key: VWBQYTRBTXKKOG-IYNICTALSA-M
• Gene Information: human ... HMGCR(3156)

Description

General description

Pravastatin sodium is an orally effective hypocholesterolaemic agent which is structurally similar to lovastatin and compactin.

Application

Pravastatin sodium salt hydrate has been used in the enzymatic method to measure mevalonic acid in serum.

Biochem/physiol Actions

Competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Inhibits cholesterol synthesis in vivo (Ki ~1 nM).

Pravastatin sodium is a competitive, water-soluble 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

Features and Benefits

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves