P5976

Anti-Platelet-Derived Growth Factor-BB antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-PDGF-BB
• MDL number: MFCD00165456
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable; western blot: suitable
• UniProt accession no.: P01127
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PDGFB(5155)

Description

General description

Platelet-Derived Growth Factor-BB (PDGF-BB) is a cystine-linked homodimer that belongs to PDGF growth factor family and is expressed mainly by vascular endothelium, megakaryocytes and Leydig cells. It has key roles in regulating neurogenesis, producing proinflammatory cytokines by orbital fibroblasts in Graves′ Ophthalmopathy, cell proliferation, development, angiogenesis and cell survival. Anti-Platelet-Derived Growth Factor-BB antibody can be used for neutralizing the biological activity of recombinant human PDGF-BB, recombinant human-AB, natural human PDGF, rat PDGF-BB, and porcine PDGF-BB. It can also neutralize recombinant human PDGF-AA at 50-100 fold high IgG concentration. Goat Anti-Platelet-Derived Growth Factor-BB antibody reacts specifically with human PDGF-BB. The product has also shown less than 10% cross-reactivity for recombinant human PDGF-AA.

Immunogen

Recombinant human PDGF-BB expressed in Escherichia coli.

Application

Anti-Platelet-Derived Growth Factor-BB antibody can be used in immunoblotting and ELISA.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline pH 7.4 with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves