P7575

L-trans-Pyrrolidine-2,4-dicarboxylic acid

≥98%

• Synonym(s): (2S,4R)-Pyrrolidine-2,4-Dicarboxylic Acid, L-trans-2,4-PDC, trans-4-Carboxy-L-proline
• Empirical Formula (Hill Notation): C₆H₉NO₄
• CAS Number: 64769-66-0
• Molecular Weight: 159.14
• MDL number: MFCD00153866
• UNSPSC Code: 12352106
• PubChem Substance ID: 24898859
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98%
• form: powder
• SMILES string: OC(=O)[C@H]1CN[C@@H](C1)C(O)=O
• InChI: 1S/C6H9NO4/c8-5(9)3-1-4(6(10)11)7-2-3/h3-4,7H,1-2H2,(H,8,9)(H,10,11)/t3-,4+/m1/s1
• InChI key: NRSBQSJHFYZIPH-DMTCNVIQSA-N
• Gene Information: rat ... Gria1(50592), Grik1(29559), Grin2a(24409), Slc1a2(29482), Slc1a3(29483)

Description

Application

L-trans-Pyrrolidine-2,4-dicarboxylic acid has been used:

• as a glutamate transport inhibitor to test its impairing effect on glutamate-induced cell death in HT22 neuronal cells
• as an analog of glutamate to test its effect on glutamate/glutamine-dependent acid resistance of E. coli and S. flexneri
• as sodium glutamate (Na⁺/Glu) cotransporter inhibitor in myogenic cell line C2C12

Biochem/physiol Actions

L-trans-Pyrrolidine-2,4-dicarboxylic acid is a selective glutamate transporter inhibitor.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves