P8399
Psoralen
≥99% (HPLC)
Synonym(s):
6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C11H6O3
CAS Number:
Molecular Weight:
186.16
Beilstein:
152784
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Quality Level
Assay
≥99% (HPLC)
form
powder
fluorescence
λex 335 nm; λem 460 nm (pH 7.0)
storage temp.
2-8°C
SMILES string
O=C1Oc2cc3occc3cc2C=C1
InChI
1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
InChI key
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
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Application
Photochemical reagent for the investigation of nucleic acid structure and function.
Psoralen has been used:
- as a crosslinker for dsRNA for in- situ hybridization studies
- in testing melanin dispersal effects in fish scale melanophores
- to test its stimulatory effects in osteoblast a cell proliferation assay
- as a reference standard in high-performance liquid chromatography (HPLC)
Biochem/physiol Actions
Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis
Features and Benefits
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Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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